Blood Levels of Mercury are Related to Autism Diagnoses – Reanalysis of Data Concludes

http://journals.sagepub.com/doi/abs/10.1177/0883073807307111

The question of what is leading to the apparent increase in autism is of great importance. Like the link between aspirin and heart attack, even a small effect can have major health implications. If there is any link between autism and mercury, it is absolutely crucial that the first reports of the question are not falsely stating that no link occurs. We have reanalyzed the data set originally reported by Ip et al. in 2004 and have found that the original p value was in error and that a significant relation does exist between the blood levels of mercury and diagnosis of an autism spectrum disorder. Moreover, the hair sample analysis results offer some support for the idea that persons with autism may be less efficient and more variable at eliminating mercury from the blood.

Ip P., Wong V., Ho M., Lee J., Wong W. Mercury exposure in children with autistic spectrum disorder. J Child Neuro. 2004;19:431434.
National Academy of Sciences. Toxicological E fects of Methylmercury. Washington, DC : National Academy Press; 2000.
Bernard S., Enayati A., Redwood L., et al. Autism: a novel form of mercury poisoning. Med Hypoth. 2001;56:462471.
Chrysochoou C., Rutishauser C., Rauber-Luthy C., et al. An 11-month-old boy with psychomotor-regression and auto-aggressive behavior. Eur J Pediatr. 2003;162:559561.
Adams JB, Romdalvic J., Sadagopa VH, Legator MS Mercury, lead, and zinc in baby teeth of children with autism versus controls . J Toxicol Environ Health. 2007;70:10461051.
Holmes AS, Blaxill MF, Haley BE Reduced levels of mercury in first baby haircuts of autistic children. Int J Toxicol. 2003; 22:277285.
Walker SJ, Segal J., Aschner M. Cultured lymphocytes from autistic children and nonautistic siblings up-regulate heat shock protein RNA in response to thimerosal challenge. Neurotoxicol. 2006; 27:685692.
Fido A., Al-Saad S. Toxic race elements in the hair of children with autism. Autism. 2005;9:290298.
Kern JK, Grannerman BD, Trivedi MH, Adams J. Sulfhydryl-reactive metals in autism. J Toxicol Environ Health. 2007;70: 715721.
Gravetter FJ, Wallnau LB Essentials of Statistics for the Behavioral Sciences. 4th ed. Pacific Grove, CA: Wadsworth ; 2005.
Tabachnik B., Fidell LS Using Multivariate Statistics. New York: Prentice Hall; 2006.
Steering Committee of the Physicians’ Health Study Research Group. Preliminary report: findings from the aspirin component of the ongoing physicians’ health study. N Engl J Med. 1988;318:262264.
Rosnow RL, Rosenthal R. Statistical procedures and the justification of knowledge in psychological science. Am Psychol. 1989;44:12761284.

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